Regarding acyclovir administration, what should the nurse assess for in the patient?

The correct answer is to assess for an increase in creatinine. This is crucial because acyclovir can be nephrotoxic, particularly in cases of dehydration or when given in high doses. Acyclovir is primarily excreted by the kidneys, and its clearance can be significantly affected if renal function is compromised. Monitoring creatinine levels provides insight into the patient’s kidney function and can help detect potential nephrotoxicity early. An increase in creatinine indicates that the kidneys are struggling to filter waste properly, which can lead to further complications.

Focusing on renal function and assessing creatinine levels helps the nurse make informed decisions about the continuation of therapy and the need for possible dose adjustments or increased hydration. By being vigilant about this parameter, the nurse can ensure safer administration of acyclovir, particularly in patients with pre-existing renal conditions or those receiving concurrent nephrotoxic medications.