What is a common side effect of statin medications?

Muscle pain or weakness is a well-documented side effect associated with statin medications. Statins, which are used primarily to lower cholesterol levels and reduce the risk of cardiovascular disease, can interfere with the normal functioning of muscle cells. This may lead to myopathy, which describes muscle pain or weakness and can range from mild discomfort to more severe conditions such as rhabdomyolysis, a serious condition that can result in kidney damage.

The mechanism behind this side effect involves the inhibition of HMG-CoA reductase, the enzyme that statins target to lower cholesterol levels. This action may affect muscle cellular processes and lead to the release of muscle enzymes into the bloodstream, signaling potential muscle damage. Regular monitoring of muscle symptoms and liver function tests is commonly recommended for patients on statins to manage this risk.