Which finding indicates a potential serious complication in a patient on spironolactone?

Spironolactone is a potassium-sparing diuretic commonly used to treat conditions such as hypertension and edematous states. One of the principal actions of spironolactone is to promote the retention of potassium while promoting the excretion of sodium and water. Therefore, the use of spironolactone can lead to an increase in potassium levels in the blood, known as hyperkalemia.

Hyperkalemia is a serious complication because elevated levels of potassium can lead to potentially life-threatening cardiac issues, such as arrhythmias. Monitoring potassium levels in patients taking spironolactone is essential since excessive potassium can disrupt normal heart rhythms and functions.

While symptoms like nausea and fatigue can be side effects associated with various medications, they are not specific indicators of a serious complication from spironolactone. On the other hand, hypokalemia is unlikely to occur with spironolactone, as this medication's mechanism is designed to prevent potassium loss. Thus, hyperkalemia stands out as a significant concern for patients on spironolactone, highlighting the need for vigilant monitoring of potassium levels during treatment.